Research

Research Topics

Zbyněk Tonar, Tereza Kubíková, Yaroslav Kolinko, Anna Malečková, Patrik Mik

Research topics:

Stereology and quantitative microscopy
Composition of vascular wall
Neurohistology
Histology of liver
Bone histology
Healing of tissues and organs supported by implanted biomaterials and tissue scaffolds
Microvessels

Jan Nevoral, Milena Králíčková
(external members from BC: Hedvika Řimnáčová, Miki Shavit, Gabriela Přibáňová, Václav Rúčka

Research topics:

Epigenetic regulations of gametogenesis and early embryonic development
Hydrogen sulfide and its gasotransmission in gametes and embryos
Mitochondrial bioegenesis during fertilization of the oocyte and early embryonic development

Řimnáčová H., Moravec J., Štiavnická M., Havránková J., Monsef L., Hošek P., Prokešová Š., Žalmanová T., Fenclová T., Petr J., Králíčková M., Nevoral J.: Evidence of endogenously produced hydrogen sulfide (H2S) and persulfidation in male reproduction 2022 doi: 10.1038/s41598-022-15360-x
Nevoral J., Zalmanova T., Hoskova K., Stiavnicka M., Hosek P., Petelak A., Petr J.: Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes. Biol Res.2018 Oct 5;51(1):38. doi: 10.1186/s40659-018-0187-2.
Nevoral J., Kolinko Y., Moravec J., Žalmanová T., Hošková K., Prokešová Š., Klein P., Ghaibour K., Hošek P., Štiavnická M., Řimnáčová H., Tonar Z., Petr J., Králíčková M.: Long-term exposure to very low doses of bisphenol S affects female reproduction. 2018 Jul;156(1):47-57. doi: 10.1530/REP-18-0092. Epub 2018 May 10.

Adamkova K., Young-Joo Yi, Petr J., Zalmanova T., Hoskova K., Jelinkova P., Moravec J., Kralickova M., Sutovsky M., Sutovsky P., Nevoral J.: SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. Journal of Animal Science and Biotechnology, 2017; 8(83). doi: 10.1186/s40104-017-0214-0. eCollection 2017
Štiavnická M., Abril-Parreño L., Nevoral J., Králíčková M., & García-Álvarez O. (2017). Non-Invasive Approaches to Epigenetic-Based Sperm Selection. Medical science monitor: international medical journal of experimental and clinical research, 23, 4677.

Jiří Polívka, Pavel Ostašov, Pavel Pitule, Anna Malečková

Research topics:

Circulating tumor cell-free DNA, micro RNA and long non-coding RNA as prognostic and predictive biomarkers of solid malignancies.
Tissue and fluid biomarkers of primary brain tumors, melanoma, colorectal cancer and lung cancer.

Pesta M, Kucera R, Topolcan O, Karlikova M, Houfkova K, Polivka J, Macanova T, Machova I, Slouka D, Kulda V. Plasma microRNA Levels Combined with CEA and CA19-9 in the Follow-Up of Colorectal Cancer Patients. Cancers (Basel). 2019 Jun 21;11(6).
Polivka J Jr, Pesta M, Pitule P, Hes O, Holubec L, Polivka J, Kubiková T, Tonar Z. IDH1 mutation is associated with lower expression of VEGF but not microvessel formation in glioblastoma multiforme. Oncotarget. 2018 Feb 20;9(23):16462-16476.
Golubnitschaja O, Polivka J Jr, Yeghiazaryan K, Berliner L. Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach. EPMA J. 2018 Aug 17;9(3):271-285.
Thiele JA, Hosek P, Kralovcova E, Ostasov P, Liska V, Bruha J, Vycital O, Rosendorf J, Opattova A, Horak J, Kralickova M, Vodicka P, Pitule P. lncRNAs in Non-Malignant Tissue Have Prognostic Value in Colorectal Cancer. Int J Mol Sci. 2018 Sep 8;19(9).

Find an automatically generated overview of publications affiliated to the Institute.

The most up-to-date study information with the planned exam dates can be found here.

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